SELE and endothelial dysfunction: After stopping GlyNAC supplementation for 8 weeks, levels of these biomarkers of endothelial dysfunction increased (sICAM1 48% increase; sVCAM1 28% increase; E-selectin 27% increase), but these values remained significantly lower than their pre-supplementation baseline values suggesting that the effects of GlyNAC supplementation on endothelial function persisted even 8 weeks after stopping GlyNAC (Table 5; Figure 4).