HSP90B2P and glaucoma: Therefore, given the high complexity of glaucoma, it is today more correct to acknowledge that many factors, including chronic inflammation (i.e., the activation of glial cells), cell dysfunctions (at TM and glia levels), mitochondrial dysfunction, oxidative stress and defects in the immune response (i.e., HSP-specific T cell responses, HSP up-regulations) all contribute to affecting the health of the cells of the eye, triggering the cascade of events that progressively leads to RGC death, optic nerve damage, and concomitant visual field loss.