INPP5D and obesity due to melanocortin 4 receptor deficiency: Furthermore, we determined the effects of caloric restriction (CR) on SHIP1-associated macrophages; the B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 ratio; and autophagy-related p62, microtubule-associated protein 1A/1B-light chain 3B (LC3B), and lysosomal-associated membrane protein 1 (LAMP1) expression to assess the therapeutic potential of modulating SHIP1 expression to treat obesity-induced metabolic syndrome.