DNAH8 and neoplasm: ESI-09 and HJC0197 induced energetic crises in tumor cells under low-glucose stress, even associated with acidosis, by three combined mechanisms: decreasing ATP production due to uncoupled respiration from ATP synthesis, increasing ATP dissipation via the reversal action of the F0F1 ATPase to maintain the mitochondrial membrane potential, and scavenging available fuels (glucose and O2) by a futile cycle of substrate oxidation.