ESI-09 might exert its anti-cancer action not only by mitochondrial uncoupling but also by EPAC inhibition because EPACs, which catalyze the exchange of guanosine 5′-diphosphate and guanosine 5′-triphosphate (GTP) on the small GTPase Rap1 and Rap2, are actively involved in cell adhesion and migration [67]. This evidence concerns the gene RAP2A and cancer.