Acidosis has also been shown to suppress rRNA/protein synthesis by inhibiting the mammalian target of rapamycin (mTOR) either via the stimulation of AMP-activated protein kinase [20] or the acid-mediated dispersion of lysosomes [23] by disconnecting ribose synthesis from the pentose phosphate pathway [21] and detaining von Hippel-Lindau tumor suppressor protein with the promoter of rRNA genes [19]. Here, MTOR is linked to Acidosis.