As expected, HIV infection was significantly associated with lower CD4 and higher CD8 T cell frequencies in the cervix (median % in the total cohort (HIV- vs HIV+): 50.5 vs 25.1 for CD4 and 32.1 vs 55.7 for CD8; p-value for both < 0.001, (S2A and S2B Fig)), similar to what is commonly described in peripheral blood. The gene discussed is CD4; the disease is HIV infectious disease.