Interestingly, focal adhesion kinase (FAK), an integrin-linked non-receptor tyrosine kinase, is also located within the chromosome 8q24 region (8q24.30) and there is evidence that FAK is amplified and overexpressed in over 40% of breast tumors, and is strongly associated with resistance to chemotherapy [17, 18] and targeted therapies (e.g., anti-PD-L1) [19, 20]. Here, PTK2 is linked to breast neoplasm.