NOS3 and osteoporosis: The latter is particularly relevant because the reduced activity of endothelial nitric oxide synthase (eNOS), the gene stimulated by shear stress decreases the bioavailability of nitric oxide leading to a pro-oxidant and inflammatory milieu associated with the pathogenesis of type 2 diabetes, heart disease, hypertension, osteoporosis, sarcopenia, as well as endometrial, colon and lung cancer [10, 11].