GRM5 and schizophrenia: A recent postmortem brain study demonstrated a significant attenuation of mGluR5 signaling in the prefrontal cortex from patients with schizophrenia, which was associated with reduced NMDA receptor phosphorylation, suggesting that disruption of reciprocal interaction between mGluR5 and NMDA signaling is integral to glutamatergic dysfunction in schizophrenia [54].