However, in the subgroup of infants with the highest quartile level of total IgE at age 24 months (ie, ≥50 IU/mL), avoiding CMF at birth significantly reduced the incidence of asthma or recurrent wheeze: 2 of 38 infants (5.3%) in the no CMF group vs 14 of 32 infants (43.8%) in the CMF group (RD, −0.385; 95% CI, −0.571 to −0.199; RR, 0.120; 95% CI, 0.030-0.490; P for interaction = .004) but not in the other quartiles of total IgE. The gene discussed is IGHE; the disease is asthma.