POLG and cataract: In summary, loss-of-function and gain-of-function experiments as well as interaction analyses elucidated a potential mechanistic basis for the relationship of OIP5-AS1 to its target gene, POLG. Herein, we used immortalized cell line B3 to investigate the specific molecular mechanisms underlying TFAP2A/OIP5-AS1/POLG axis in cataract pathopoeias in vitro.