GPBAR1 and cancer: In addition, M2-mAchR/Src signaling was found to be involved in DCA induced TLR2 tyrosine phosphorylation, an important parallel phenomena was described for EGFR, which is also transactivated by bile acids in a muscarinic receptor-dependent or TGR5-mediated manner and contributes to the cancer cell proliferation and survival,24,30,40 thus crosstalk between bile acid receptor and other co-expressed receptors may represent an important fashion that bile acids play their diverse roles, and the regulation of intermediate process should be further elucidated.