IRF3 and hepatocellular carcinoma: As shown in Figure 2, the transcriptional levels of XRCC5, IRF3, TRIM21, STAT6, DDX41, TBK1, XRCC6, TREX1, PRKDC (all P<0.001) and TMEM173 (P<0.05) in HCC tissues were significantly upregulated (Figure 2A–C,E,G–L).