In addition, the increase in the expression of XRCC5, TRIM21, IFI16, STAT6, NLRC3, TBK1, XRCC6, and PRKDC was significantly related with the expression of Treg and T-cell exhaustion gene markers, such as FOXP3, STAT5B, TGFβ1, PDCD1, CTLA4, HAVCR2, and LAG3 in patients with HCC. This evidence concerns the gene TRIM21 and hepatocellular carcinoma.