TREX1 and neoplasm: Figure 4L shows that the highest mRNA expression of TMEM173 was found in stage 1. Similarly, the highest mRNA expression of XRCC5, IRF3, DDX41, TBK1, XRCC6, and PRKDC was found in grade 4 tumors (Figure 5A,B,G–I,K), while the highest mRNA expression of TRIM21, STAT6, and TMEM173 was found in grade 3 (Figure 5C,E,L). However, the highest mRNA expression of IFI16 and TREX1 was found in grade 1 or 2; as the tumor grade increased, their mRNA expression tended to be lower (Figure 5D,J).