Moreover, in patients with HCC, high expression of mRNA and protein was found in cGAS-STING pathway member genes, including XRCC5, IRF3, TRIM21, STAT6, DDX41, TBK1, XRCC6, TREX1, PRKDC, and TMEM173. The gene discussed is TREX1; the disease is hepatocellular carcinoma.