Collectively, the results suggest that cGAS-STING pathway members (e.g., XRCC5, TRIM21, IFI16, STAT6, NLRC3, TBK1, XRCC6, and PRKDC) may play a crucial role in the regulation and recruitment of immune infiltrating cells in HCC. The gene discussed is TRIM21; the disease is hepatocellular carcinoma.