However, the mRNA expression of IRF3 (P=0.34), TRIM21 (P=0.07), DDX41 (P=0.14), TBK1(P=0.051), and TREX1 (P=0.14) did not show a correlation with prognosis in patients with HCC (Figure 6B,C,G,H,J). The gene discussed is TREX1; the disease is hepatocellular carcinoma.