Mutations in LRP2 have been previously associated with left ventricular non-compaction (LVNC) as well as other congenital heart defects in mouse (Baardman et al., 2016) and in Donnai-Barrow Syndrome in humans (Baardman et al., 2016; Kantarci et al., 2008). This evidence concerns the gene LRP2 and congenital heart disease.