For example, the researches of Wang, X etc. indicated that Gas5 could promotes osteogenic differentiation of bone marrow mesenchymal stem cells by FOXO1 in mouse (Wang et al., 2019).However, the effect of GAS5 on human osteoblast differentiation and its role in osteoporosis have not been clearly clarified. The gene discussed is GAS5; the disease is osteoporosis.