DPP4 and type 2 diabetes mellitus: Since oral bacteremia occurs as a result of mastication, toothbrushing, and dental procedures (Tomás et al., 2012), the higher incidence of periodontopathic bacteremia in individuals suffering from severe periodontal disease seems to exacerbate type 2 diabetes mellitus through degradation of incretins by bacterial DPP4 in the bloodstream.