Briefly, concerning AD-causative genes (Table 2), we identified two known missense variants, Glu318Gly in PSEN1 (patients 1 and 2) and Arg71Trp in PSEN2 (patient 3), and a novel silent variant, Ser236Ser in PSEN2 (patient 4). The gene discussed is PSEN1; the disease is Alzheimer disease.