S6 phosphorylation and GLUT1 expression have a key role of glucose uptake; therefore, they could be a biomarker of malignancy of IPMN when S6 phosphorylation or GLUT1 expression can be easily detected using pancreatic juice in the future. This evidence concerns the gene SLC2A1 and pancreatic intraductal papillary-mucinous neoplasm.