NOD2 and Granuloma: Several factors have been described in the literature including active smoking, penetrating or perforating behavior, perianal disease, prior intestinal resection, extensive small bowel resection (>50 cm), type of anastomosis, postoperative complications, resection margins, age at diagnosis of disease, gender, location and duration of disease, granuloma, family history, CRP level, myenteric plexitis, NOD2/CARD15 mutation, increased TGF‐b, and low II10 mRNA level.11, 12, 24