Extracellular HSP70 induces EMT via the p38 MAPK signaling pathway in HCC cells [5], whereas EGF, a ligand of EGFR as TGF-α, induces EMT via the activation of the p44/p42 MAPK and AKT signaling pathways in HCC [28, 29]. The gene discussed is EGFR; the disease is hepatocellular carcinoma.