Also, Gu et al. found that overexpression of lncRNA MEG3 was able to suppress pancreatic cancer activity by regulating PI3K/AKT/Bcl‐2/Bax/Cyclin D1/P53 and PI3K/AKT/MMP‐2/MMP‐9 signaling pathways (Figure 3).101. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.