Synthetic lethality has also be reported with other HR related proteins including BRCA1, PALB2, FAM175A (ABRAXAS), and BARD1 in breast cancer cells where a more specific PARGi, PDD00017273, was used and on-target effects validated using two independent PARG siRNA (Gravells et al., 2017). The gene discussed is BRCA1; the disease is breast carcinoma.