However relevant to the thesis here, selective deletion of UDP-glucose: N-acylsphingosine D-glucosyltransferase in subsets of adult forebrain neurons has been shown to improve spatial memory and overcome loss of dendritic spines in the hippocampus of 5x familial AD mice, which model Alzheimer disease (Herzer et al., 2018). The gene discussed is UGCG; the disease is early-onset autosomal dominant Alzheimer disease.