The studies have found that FAM83D could not only affect cell proliferation and motility through the tumor suppressor gene FBXW7 (Mu et al., 2017) or ERK1/ERK2 signaling cascade (Wang et al., 2015), but also affect breast cancer cell growth and promote epithelial cell transformation through MAPK signaling (Cipriano et al., 2013; Cipriano et al., 2014; Lee et al., 2012). The gene discussed is MAPK3; the disease is breast cancer.