‘Does IFN-γ contribute to immune-mediated tumor regression or does it stimulate cancer growth?’ ‘Can we predict the effects of IFN-γ after introducing it to tumors?’ ‘What components of the TME interplay with IFN-γ and how do they do so?’ These and many other questions remain to be answered, if we want to understand and benefit from IFN-γ-mediated antitumor immunity. Here, IFNG is linked to neoplasm.