Subsequent multivariable analysis using the least absolute shrinkage and selection operator (LASSO) logistic regression (Fig. 2) and the filter method [20] (supplement material 1) selected Fibroscan results, platelet count, AST, PT, PIIINP, type IV collagen, laminin, HA and diameter of portal vein as input parameters of diagnostic models for significant fibrosis and cirrhosis. The gene discussed is F2; the disease is Cirrhosis.