Since IFN‐γ monofunctional T cells contrast significantly at the level of transcription from IFN‐γ multifunctional cells as observed in different human infections,55 our data suggest after human infection with S. Typhi, there is preferential induction of multifunctional CD8+ TEM cells within the memory compartment, and only multifunctional IFN‐γ+CD8+ TEM cell responses are significantly cross‐reactive. The gene discussed is IFNG; the disease is infection.