We observed that ST, PA and iNTSTy all had strong correlations in magnitude of frequencies of IFN‐γ+ CD8+ TEM cells at baseline with the magnitude of the peak of the IFN‐γ+ CD8+ TEM cell response against the respective invasive strain after oral S. Typhi challenge (Figure 6a–c), suggesting that S. Typhi challenge expands baseline reactive CD8+ T cells as part of the response to infection. The gene discussed is CD8A; the disease is infection.