To better understand the phenotypic attributes of Mtb‐specific CD4 T cells that associate with TB disease extent, we compared the expression of HLA‐DR (activation marker), CD27 (memory marker), IL‐2 (functional potential), CD153 (TNF superfamily member, implicated in Mtb protection), KLRG1 (co‐inhibitory molecule) and MIP‐1β (chemokine, CCR5 agonist) in the LTBI group and the aTB cohort (at baseline and week 24; Figure 3a and b). The gene discussed is CD27; the disease is tuberculosis.