Although the CB-839 glutaminase inhibitor was not effective on tumor growth of both xenografts when administered as monotherapy, its combined utilization with the BKM120 aldolase inhibitor had a synergistic effect by increasing the tumor growth inhibition (TGI) from 37 to 70% (p < 0.05) and from 47 to 66% (p < 0.05) for A549 and HCT116 xenografts, respectively, as indicated by caliper measurement over a 14 days window (Fig. 3a and c) and by post-mortem weight determination (Figure S1D and E). This evidence concerns the gene GLS and neoplasm.