For example, a study conducted by Zhang et al. [35] found significant negative correlations between TIMP-1 immunoreactivity and depth of invasion and lymph node metastasis, though a study conducted by Mroczko et al. [36] reported that expression of TIMP-1 in cancer tissue correlated positively with the depth of tumour invasion and nodal metastasis. Here, TIMP1 is linked to neoplasm.