In the T2DM patients, the serum adipsin level was positively correlated with BMI (P < 0.001), waist circumference (P < 0.001), fasting serum insulin (P < 0.001), HOMA-IR (P = 0.006), and the FIB-4 index (P = 0.028) and negatively correlated with eGFR (P = < 0.001) (Table 4). Here, INS is linked to type 2 diabetes mellitus.