In the T2DM patients, after adjustments for age and sex (Model 1), the serum adipsin levels were positively correlated with BMI (P < 0.001), waist circumference (P < 0.001), fasting serum insulin (P < 0.001), HOMA-IR (P = 0.006), CPR-index (P = 0.031), and the FIB-4 index (P = 0.045), and were negatively correlated with eGFR (P < 0.001) (Table 5). Here, INS is linked to type 2 diabetes mellitus.