APOB rs693 [41], rs2854725 [42] and rs1367117 [43, 44] were associated with serum APOB levels, further associated with familial hypercholesterolemia [45] and heart-related traits [46], predicted the risk of CHD [42], maternally-derived effect on BMI [43].There were fewer studies about APOA SNP rs9804646, rs10047462, rs888246 and APOB rs12713956. Here, APOB is linked to familial hypercholesterolemia.