APOA-I SNPs rs9804646 and rs888246 were associated with insulin resistance (OR = 0.856, 95% confidence interval [CI] 0.756–0.968, P = 0.013; OR = 1.340, 95% CI 1.069–1.680, P = 0.011) after adjustment. The gene discussed is APOA1; the disease is Insulin resistance.