APOA-I GRS decreased insulin resistance (OR = 0.923, 95% CI 0.880–0.968, P < 0.001) and MetS (OR = 0.886, 95% CI 0.845–0.929, P < 0.001) significantly, which remained after adjusting for age, gender, and BMI (all P < 0.001). Here, APOA1 is linked to metabolic syndrome.