APOA-I SNPs rs964184, rs9804646, and rs888246 were significantly associated with MetS (OR = 1.353, 95% CI 1.201–1.523, P < 0.01; OR = 0.777, 95% CI 0.69–0.874, P < 0.01; OR = 1.274, 95% CI 1.024–1.586, P = 0.03, respectively) after adjustment. The gene discussed is APOA1; the disease is metabolic syndrome.