F. Briand fed hypercholesterolemia hamsters with Saccharomyces boulardii CNCM I-745, and CNCM I-745 significantly reduced the expression of ABCG5 and ABCG8 in hypercholesterolemia and increased the expression of HMG CoA-R gene (encoding a rate-limiting enzyme of cholesterol synthesis). The gene discussed is ABCG5; the disease is Hypercholesterolemia.