Recently, some studies have indicated that increased tumor mutation loads were associated with survival benefit from both anti-CTLA-4 and anti-PD-1 therapy in multiple malignancies such as melanoma (Hugo et al., 2016), lung cancer (Rizvi et al., 2015), and esophagogastric cancer (Greally et al., 2019). This evidence concerns the gene CTLA4 and neoplasm.