Also, a loss of calsyntenin-1 (CLSTN1) induced alterations to amyloid precursor protein (APP) processing (Vagnoni et al., 2012), and neuronal pentraxin 1 (NPTX1) was implicated in synaptic function dysregulation during AD progression (Cummings et al., 2017). The gene discussed is NPTX1; the disease is Alzheimer disease.