Except for CRYM, GABRD, PHYHIP, SCN2B, and TERF2IP in GSE36980 and CAMKK2, PHYHIP, and GPR158 in GSE132903, all other hub genes were significantly down-regulated in AD samples from the five datasets (P < 0.05, 0.01, 0.001, or 0.0001; Figure 6 and Supplementary Figure 7). The gene discussed is PHYHIP; the disease is Alzheimer disease.