IL-33/ST2 signaling pathway has been implicated in tumor-associated immune response and inflammatory disease of the lung (Casciaro et al., 2019), and IL-33 could significantly promote the migration and invasion of lung cancer cells through alpha serine/threonine-protein kinase (AKT) pathway activation (Yang et al., 2018). This evidence concerns the gene IL1RL1 and lung carcinoma.