Among which the correlation between BC and decreased methylation of S100P_CpG_2.3, S100P_CpG_9, and S100P_CpG_10.11.12 was significant (per −10% of methylation, OR = 0.46 for S100P_CpG_2.3, OR = 0.61 for S100P_CpG_9, and OR = 0.55 for S100P_CpG_10.11.12; all p < 0.05; Table 2). The gene discussed is S100P; the disease is breast cancer.