HYAL2 and breast cancer: To understand the differential DNA methylation patterns between ethnicities, we took a closer look at the DNA methylation loci in S100P and HYAL2. The methylation levels of S100P and HYAL2 CpG sites in healthy Chinese individuals are all lower than that of healthy Europeans (Yang et al., 2015, 2017), but the methylation levels are mostly similar in BC cases of the two ethnic groups.