The current study showed an association between increased methylation of S100P and BC (S100P_CpG_2.3, S100P_CpG_4, S100P_CpG_9, and S100P_CpG_10.11.12; all p ≤ 0.05; Figure 1A), which is contrary to the previous report in Caucasians that BC was associated with decreased methylation of S100P (Yang et al., 2017). This evidence concerns the gene S100P and breast cancer.