NPC1 and nasopharyngeal carcinoma: The overactivation of INFS in the subcortical region and its inactivation in the cortex is thought to underlie the premature NPC development in subcortical loci and an impaired development in the organoid cortex, as shown in cultured NPC and organoids (Stachowiak et al., 2017; Chuye et al., 2018).