Wang et al. [12] uncovered that in laryngeal cancer cells demethylated SP1 sites in CG-rich region of miR-23a-27a-24–2 cluster promoter upregulate the cluster expression, resulting in early apoptosis inhibition and proliferation promotion probably via targeting the related targets such as PLK2 and APAF-1.On the basis of 77 LSCC patients, Liu et al. [13] found that hypermethylation percentage RUNX3 was associated with lymph node metastasis,TNM classification of malignant tumors stage, poor OS rate as well as suppression of RUNX3 expression. This evidence concerns the gene RUNX3 and cancer.