EGFR and cancer: The level of risk score for MDGPS was considered as the phenotypes, and the findings uncovered that high-risk level of MDGPS may closely correlated with several important crosstalk, comprising of calcium signaling pathway, ECM receptor interaction, ErbB signaling pathway, mTOR signaling pathway, pathways in cancer, MAPK signaling pathway, Notch signaling pathway, RNA degradation, TGF beta signaling pathway (Fig. 4).