To explore potential biological pathways for 5 RFS-related MDGs, we carried out the GSEA and indicated that 5 MDGs of MDGPS was mainly scattered in cancer-related pathways (ErbB signaling pathway, mTOR signaling pathway, MAPK signaling pathway, Notch signaling pathway), metabolism-related pathways(calcium signaling pathway, RNA degradation) and immune-related biological processes (T cell receptor signaling pathway). The gene discussed is MTOR; the disease is cancer.