Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) or receptor tyrosine kinase pathways [9] that mediate cytokine-induced immunologic responses, and it has been demonstrated that abnormal expression of SOCS is involved in the occurrence and progression of human cancers. Here, CISH is linked to cancer.