We further demonstrate that MDM2 is a direct target of miR-585 in glioma cells, and that the restoration of MDM2 substantially rescues miR-585 effect on glioma cell proliferation, thus establishing that the inhibitory effect of miR-585 on glioma cell proliferation depends on directly targeting MDM2 (Fig. 6). This evidence concerns the gene MDM2 and central nervous system cancer.