miR-585 functions as a tumor suppressor in gastric cancer and NSCLC, as manifested by the inhibited proliferation, migration, and invasion of cancer cells when miR-585 is overexpressed, in which MAPK1 and hSMG-1 are molecular targets and mediate the tumor-suppressive effects of miR-585, respectively [15, 16]. The gene discussed is SMG1; the disease is gastric cancer.