Compared with EGFR-mutant tumors, ROS1-rearranged tumors were less likely to have air-bronchogram (p = 0.011) and pleural retraction (p = 0.048) but more likely to have pleural effusion (p = 0.025), pericardial metastases (p < 0.001) (Fig. 3B), intrathoracic and extrathoracic lymph node metastases (p = 0.047 and 0.023, respectively) (Figs. 1, 2, 3), and brain metastases (p = 0.017). The gene discussed is ROS1; the disease is Pleural effusion.