The glucose tolerance test showed that the blood glucose AUC was significantly higher in the DBP group compared to the Ctrl group, and was higher at 30 min and 60 min, as shown in Fig. 2A. In addition, the insulin tolerance test showed higher blood glucose levels in the DBP group than in controls at 15 min, 30 min and 60 min after insulin injection (Fig. 2B), indicating that DBP exposure could lead to insulin resistance. This evidence concerns the gene INS and Insulin resistance.