In contrast genes involved in development and differentiation (Arid5b, Inmt, Grem2, Gdap10), cell metabolism (Alas1, Gsta1, Thrsp, Fdft1, Elovl6), tumor growth (SerpinA4, Cish, Rpl36), and cell cycle control (PLK3, Myc, HNF6/Onecut1) were downregulated (Fig. 3C, Table 1). The gene discussed is GREM2; the disease is neoplasm.