To this purpose, four CRC cell lines (SNU1235, SNU1047, HT29, and LS180), differing for BRAF and PTEN status (BRAFV600E/PTEN-loss, BRAF-wt/PTEN-loss, BRAFV600E/PTEN-competent, BRAF-wt/PTEN-competent) were exposed to increasing concentration of drugs for 24 h. Here, PTEN is linked to colorectal carcinoma.