BRAF and colorectal carcinoma: As shown in Fig. 4a, mRNA modulation closely paralleled protein expression data: dabrafenib differentially affected IL-8 mRNA expression depending on the genetic context of the CRC cells (strong down- and upregulation in BRAFV600E and BRAF-wt contexts, respectively), while trametinib downregulated IL-8 mRNA levels regardless of BRAF status.