IL-8 production was profoundly influenced by modulation of the MAPK pathway: in particular, BRAF inhibition by dabrafenib abrogated IL-8 production in BRAF-mut cell lines, but paradoxically increased it in BRAF-wt contexts, while MEK inhibition and Extracellular signal-Regulated Kinase (ERK)2 silencing selectively abrogated IL-8 production, regardless of the genetic background of the CRC cell lines examined. Here, MAPK1 is linked to colorectal carcinoma.