CXCL8 and cancer: InterLeukin (IL)-8, also referred to as CXCL8, is a proinflammatory CXC ELR + chemokine; through the binding to its cell-surface G protein-coupled receptors, CXCR-1 and CXCR-2, IL-8 plays multiple roles in cancer, driving the activation of key signaling pathways in both stromal and intestinal epithelial cells, to promote or increase proliferation, angiogenesis and metastasis3.