Notably, significant elevations in IL-2 expression in the AT together with that of other inflammatory mediators (IL-8, IL-12A, CCL5, CCL19, CCR2 and CCR5 and TLRs) in obesity suggests that these factors may contribute cooperatively for insulin resistance induction in this population. The gene discussed is IL12A; the disease is obesity due to melanocortin 4 receptor deficiency.