Notably, significant elevations in IL-2 expression in the AT together with that of other inflammatory mediators (IL-8, IL-12A, CCL5, CCL19, CCR2 and CCR5 and TLRs) in obesity suggests that these factors may contribute cooperatively for insulin resistance induction in this population. This evidence concerns the gene CCR2 and obesity due to melanocortin 4 receptor deficiency.