Interestingly, depletion of Hdac6 expression further reduces this time in both WT and CF backgrounds (WT: 28.3 ± 4.6 s; CF: 17.6 ± 3.8 s; DKO: 3.6 ± 1.9 s) (Fig. 2B). Here, HDAC6 is linked to cystic fibrosis.