CF mice at 4-weeks of age display significantly reduced open arm time (OAT) suggesting the presence of more anxiety compared to the WT counterparts (WT: 34.6 ± 10.3 s; CF: 16.6 ± 5.2 s), however, loss of Hdac6 expression did not significantly change OAT in DKO mice compared to CF mice at 4-weeks of age (DKO: 11.8 ± 4.6 s) (Fig. 2A). Here, HDAC6 is linked to cystic fibrosis.