HDAC6 and cystic fibrosis: As seen in the combined gender analysis, 4-week old CF males exhibited significantly reduced total distance traveled when compared to wild-type (WT: 625.1 ± 107.8 cm; CF 348.9 ± 35.2 cm), which again was not normalized by the removal of Hdac6 (DKO: 331.3 ± 60.0 cm) (Fig. 1B).