Depletion of Hdac6 expression in the DKO mice did not significantly increase distance traveled compared to CF mice (4wk: DKO: 800.1 ± 144.7 cm/8wk: DKO: 1266.2 ± 154.4 cm) (Fig. 3A,B). The gene discussed is HDAC6; the disease is cystic fibrosis.