Depletion of Hdac6 expression in 8-week old mice resulted in decreased open area traveling time suggesting a potential increase in anxiety-like behavior (WT: 33.9 ± 6.4 s; CF: 41.1 ± 6.4 s; HDA: 11.0 ± 1.6 s: DKO: 20.6 + 5.0 s) (Fig. 4B). Here, HDAC6 is linked to Anxiety.