We then selected five SNPs for genes expected to affect CAD development, including cubilin (CUBN), HNF1 homeobox A (HNF1A), and LIPC. The CUBN gene is located on 10p13 and encodes cubilin, an extracellular binding protein with various ligands, including intrinsic factor-vitamin B12, vitamin D-binding protein, apolipoprotein, and HDL-cholesterol9. This evidence concerns the gene CUBN and coronary artery disorder.