Unlike the other genotypes, the CUBN rs2291521GA + AA genotype was associated with increased CAD risk in conjunction with folate < 4.02 nmol/L and vitamin B12 < 440 pg/mL (AOR = 4.111; 95% CI 1.804–9.368, and AOR = 3.756; 95% CI 1.208–11.676, respectively). This evidence concerns the gene CUBN and coronary artery disorder.