The CUBN rs2291521GA + AA and HNF1A rs55783344CT + TT genotypes dramatically increased the risk of CAD in association with LDL-cholesterol ≥ 130 mg/dL (AOR = 3.109; 95% CI 1.201–8.045, and AOR = 3.924; 95% CI 1.416–10.875, respectively). Here, CUBN is linked to coronary artery disorder.