The CUBN rs2291521GA/LIPC rs139204AA and HNF1A rs55783344CT/LIPC rs17269397AA genotype combinations were associated with increased risk of CAD (AOR = 1.874; 95% CI 1.299–2.703; P = 0.001 and AOR = 1.474; 95% CI 1.058–2.054; P = 0.022, respectively), and the CUBN rs2291521GA/HNF1A rs55783344CT genotype combination in particular exhibited a synergistic effect (AOR = 2.622; 95% CI 1.518–4.526; P = 0.001). Here, CUBN is linked to coronary artery disorder.