Among the families where the parental phenotype data is available, one proband also carries a de novo missense variant (p.Arg1241Gln, CADDv1.3 = 15.4) in SHANK2 in addition to the paternally transmitted stop-gain variant (p.Arg860Ter) in CDK13, although the de novo variant is more likely to contribute to the proband’s autism. The gene discussed is CDK13; the disease is autism.