IL6 and neoplasm: The possible antibody-mediated pathologic mechanisms in PNP associated neoplasias are listed as follows: Tumor-induced production of autoantibodies targeting epithelial proteins; Cross-reactivity of neoplasm and epithelial antigens; Elevated IL-6 leading to abnormal B-cell differentiation and auto-immunoglobulin production; Epitope spreading (interface dermatitis induced by the neoplasia exposes epidermal epitopes with autoantibody production against multiple epidermal proteins)3,22.