Of note, knockdown of DRP1 in PINCH-1 KO lung adenocarcinoma cells (Fig. 7a, e), but not that in PINCH-1 expressing wild type lung adenocarcinoma cells (Supplementary Fig. 4d, e), significantly increased the level of PYCR1 and proline synthesis. The gene discussed is PYCR1; the disease is lung adenocarcinoma.