In addition to showing that PINCH-1 regulates proline synthesis, cell proliferation, collagen matrix deposition, and tumor growth and revealing a signaling axis consisting of PINCH and DRP1 that functions in regulation of these processes, the findings presented in this paper suggest that the function of DRP1 in regulation of proline synthesis and cell proliferation is context (i.e., PINCH-1) dependent. This evidence concerns the gene DNM1L and neoplasm.