Consistent with the results from cultured lung adenocarcinoma cells (Figs. 4 and 6), ablation of PINCH-1 from lung adenocarcinoma significantly increased the protein (Fig. 9a) and mRNA (Fig. 9b) levels of DRP1 and reduced the levels of PYCR1 (Fig. 9a) and proline (Fig. 9c) in vivo. This evidence concerns the gene PYCR1 and lung adenocarcinoma.