LIMS1 and neoplasm: Furthermore, the level of collagen matrix (Fig. 9d), of which 25% amino acids were derived from proline, as well as cell proliferation (Figs. 2b, d, 3b–d, 5g–i, 8c, d) and tumor growth (Fig. 10a–e) were markedly reduced in response to loss of PINCH-1, resulting in significant improvement of the mortality rate of mice bearing lung adenocarcinoma (Fig. 10f).