LIMS1 and lung adenocarcinoma: However, in contrast to the pro-proliferation role of DRP1 in PINCH-1 expressing lung adenocarcinoma cells, knockdown of DRP1 from PINCH-1 deficient lung adenocarcinoma cells (Fig. 5a), which expressed an elevated level of DRP1 (Fig. 4a) and exhibited excessive mitochondrial fragmentation (Fig. 2e–g), increased cell proliferation (Fig. 5g–5i).